Mercury Toxicity

Dental Amalgam and Mercury in Dentistry

Mercury in dentistry has re-emerged as a contentious issue in public health, predominantly because so many people are inadvertently exposed to mercury in order to obtain the benefits of dental amalgam fillings, and the risks remain difficult to interpret. Evidence on the health effect of dental amalgams comes from studies of the association between their presence and signs or symptoms of adverse effects or health...

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Blood Mercury Levels of Dental Students and Dentists at a Dental School

To determine the blood mercury levels in dental students and clinical teaching staff in a dental school using amalgam as a restorative material. There were statistically significant increases (p<0.001) in plasma mercury concentration between measurements in all groups at the end of the academic year. Red cell mercury levels were also consistently elevated. Although the highest levels of mercury were recorded in persons working with...

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Comparison of the Interaction of Methyl Mercury and Mercuric Chloride with Murine Macrophages

The toxicity of organic methyl mercury was studied on murine macrophages in cell culture and compared to that of inorganic mercuric chloride. Long-term treatment of macrophage cultures with methyl mercury resulted in decreased cell viability in a concentration-dependent fashion. Experiments showed that 20 microM methyl mercury was highly toxic, causing cell death within a few days, while cultures exposed to lower levels were less severely...

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Possible Roles of Nitric Oxide and Redox Cell Signaling in Metal-Induced Toxicity and Carcinogenesis: A Review

Toxic doses of transition metals are capable of disturbing the natural oxidation/reduction balance in cells through various mechanisms stemming from their own complex redox reactions with endogenous oxidants and effects on cellular antioxidant systems. The resulting oxidative stress may damage redox-sensitive signaling molecules, such as NO, S-nitrosothiols, AP-1, NF-kappaB, IkappaB, p53, p21ras, and others, and thus derange the cell signaling and gene expression systems. This,...

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Molecular Mechanisms of Metal Toxicity and Carcinogenesis

Many metals and metal-containing compounds have been identified to be potent mutagens and carcinogens. Recently, a new sub-discipline of molecular toxicology and carcinogenesis has been developed. The combination of newly developed molecular techniques and free radical approach makes it possible to insightfully examine metal-induced carcinogenesis in precise molecular terms so that intricate biological interrelationships can be elucidated. In consideration of the increased amount of new...

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