Cavitations — The Silent Killer

You probably already know that having a root canal can be a traumatic experience, but did you realize that by having a root canal, you are automatically put into the category of people who could suffer long term, and none too pleasant effects from the procedure? The same holds true for people who have had tooth extractions, had their wisdom teeth taken out, or have suffered a variety of other abcesses, injuries to the teeth and jaw. This is not to say that everyone undergoing the above will ultimately develop health issues as a result, but evidence is mounting that a huge percentage of us are at risk.

The Culprit

A cavitation is an infected hole in your jaw bone

Ultimately the perpetrator is bacteria … bacteria that were not neutralized or adequately flushed out after an oral surgery or extraction. Once trapped inside the post-surgery cavity these bacteria can incubate for years, leaking toxic residue into the blood stream and causing a host of health issues, both local to the jaw and other areas of the body. In addition to bacteria, sometimes this area will host other harmful elements including viruses, fungi and parasites. In other words, when a root canal is performed on a tooth, bacteria from within that tooth may produce very strong chemicals that are highly neurotoxic. Research has shown these toxins can then combine with chemicals or heavy metals, such as mercury, and form even more potent toxins. These neurotoxins can over time be released into the bloodstream where they destroy many otherwise critically important enzymes within the body.

This scenario can happen under what dentists consider the “normal” extraction situation: the tooth is removed but the ligament that holds the tooth in place is left behind and the area isn’t properly cleaned, and consequently toxins remain within the ligament that slowly seep into the body, potentially creating chronic health issues and other symptoms most doctors can’t diagnose (such as fibromyalgia, heart issues, endocrine issues, neurological issues, among others).

Worst Case Scenario

You might think it’s bad enough to think about having neurotoxic bacteria, fungus and other unsavory creatures swimming in the open spaces between your teeth and gums, but there actually is one thing worse; cavitations (also called osteomyelitis, osteonecrosis, or a “hole in the bone”). Now, cavitations are exactly what they sound like they are; a hollowed out area or hole – and in this case, a cavern occurs when all too active bacteria has successfully departed the original post-surgical site and has somehow begun to impress itself into the actual jawbone. Every additional hole created by this process is filled with decaying bone and tissue that leaves behind an ever greater potential for bacteria (and their unsavory cohorts and associated neurotoxins) to flourish and grow. Eventually this caustic soup of poison leaks into the blood stream where it can cause or exaggerate other existing health issues in the body.

How do you know if you have a cavitation?

Although cavitations can go undetected for years in an otherwise healthy person, jaw pain sometimes occurs in patients suffering from bone lesions and sometimes jaw pain will manifest after a sinus infection, which can then also lead to the discovery of a cavitation. But it seems that the vast majority of people seeking to discover whether or not they have cavitations are those also suffering from other chronic health issues. It is the overriding health condition that has brought them back to the dentist seeking ways to cut down on potential toxins flowing into the bloodstream.

The first step in successfully diagnosing cavitations can be made using a variety of diagnostic tools which can include a unique ultrasound device developed specifically for this purpose called a Cavitat, CAT scans and MRI’s. The best method of detection is through a ConeBeam CT Scan (CBCT) and applied kineseology (AK) or muscle testing.

Treatment

Once properly diagnosed, treatment for a cavitation commonly starts by surgically removing any dead bone, tissue and other debris. Additional treatment options include the use of lasers and ozone treatments as well as probiotics and other natural products/techniques. Once applied, these methods help to create a clean and sterile environment that promotes healing at the site, and ultimately throughout the body.

Additional information: INCIDENCE LEVELS AND CHRONIC HEALTH EFFECTS RELATED TO CAVITATIONS www.thenaturalrecoveryplan.com/docs/research_docs/2010.07.28.03.27_Cavitations.pdf

Cysteine Metabolism and Metal Toxicity

Chronic, low level exposure to toxic metals is an increasing global problem. The symptoms associated with the slow accumulation of toxic metals are multiple and rather nondescript, and overt expression of toxic effects may not appear until later in life. The sulfhydryl-reactive metals (mercury, cadmium, lead, arsenic) are particularly insidious and can affect a vast array of biochemical and nutritional processes. The primary mechanisms by which the sulfhydryl-reactive metals elicit their toxic effects are summarized. The pro-oxidative effects of the metals are compounded by the fact that the metals also inhibit antioxidative enzymes and deplete intracellular glutathione. The metals also have the potential to disrupt the metabolism and biological activities of many proteins due to their high affinity for free sulfhydryl groups. Cysteine has a pivotal role in inducible, endogenous detoxication mechanisms in the body, and metal exposure taxes cysteine status. The protective effects of glutathione and the metallothioneins are discussed in detail. Basic research pertaining to the transport of toxic metals into the brain is summarized, and a case is made for the use of hydrolyzed whey protein to support metal detoxification and neurological function. Metal exposure also affects essential element status, which can further decrease antioxidation and detoxification processes. Early detection and treatment of metal burden is important for successful detoxification, and optimization of nutritional status is paramount to the prevention and treatment of metal toxicity.

Quig D. Altern Med Rev. 1998 Aug; 3(4):262-70. 9727078 PubMed.

Comparison of the Interaction of Methyl Mercury and Mercuric Chloride with Murine Macrophages

The toxicity of organic methyl mercury was studied on murine macrophages in cell culture and compared to that of inorganic mercuric chloride. Long-term treatment of macrophage cultures with methyl mercury resulted in decreased cell viability in a concentration-dependent fashion. Experiments showed that 20 microM methyl mercury was highly toxic, causing cell death within a few days, while cultures exposed to lower levels were less severely affected. Comparison of the toxicity of organic and inorganic mercury by cell viability showed no difference between equimolar concentrations of methyl mercury and mercuric chloride. Furthermore, protein synthesis (interferon-alpha/beta) was reduced in a concentration dependent manner and had the same reduced magnitude in cells treated with either methyl mercury or mercuric chloride. However, impairment of random migration and phagocytosis of macrophages appeared at lower concentrations in cells exposed to methyl mercury than in cells exposed to mercuric chloride. Electron microscopy of cells exposed to methyl mercury revealed mercury deposits in lysosomes and dispersed in the cytoplasm and nuclei. The present study shows that methyl mercury and mercuric chloride impair cell viability and protein production in cell cultures at equimolar concentrations, while methyl mercury inhibits macrophage functions such as migration and phagocytosis at lower concentrations than mercuric chloride.

Christensen MM, Ellermann-Eriksen S, Rungby J, Mogensen SC. Arch Toxicol. 1993; 67(3):205-11. 7684221 PubMed

Autism Treatments: Heavy Metal Detoxification and Metallothionein Promotion

Recent developments have been made to promote metallothionein (MT) in the G.I. tract, brain, and elsewhere. This protocol is based on 1,200 published articles describing MT synthesis, activation, and redox mechanisms. A total of 22 nutrients that enhance MT production were identified and tested in informal clinical trials involving staff and volunteer autism families. We found that aggressive zinc loading must precede full-scale MT Promotion therapy for best results. Each molecule of MT requires 7 atoms of zinc (Zn) for proper functioning. Premature synthesis of MT at intestinal mucosa can temporarily prevent Zn transport into the bloodstream, resulting in severe irritability. Our best clinical outcomes were achieved using a two-phase protocol: Preloading with Zn and augmenting nutrients, followed by: Cautious, gradual introduction of MT promotion nutrients. Treatment for Patients Found to Have Metallothionein Dysfunction

A good trial of the gluten-free, casein-free diet (at least 6 months) is highly recommended.

Step 1
a. Gut Clean-up – restore good levels of friendly bacteria and reduce overgrowths of   unfriendly organisms such as Clostridia and yeast

b. Supporting Nutrients – exact nutrients determined by testing
c. Reduction of elevated plasma ammonia (if necessary)

d. Aggressive zinc pre-loading
e. DMSA alone until very little mercury, lead or tin is excreted in urine (if necessary)

Step 2 – MT Promotion Protocol
Phase 1: Zinc Loading: Aggressive supplementation with Zn and augmenting nutrients for 4 to 8 weeks is recommended. Sensitive patients may require gradual build-up of Zn dosage. Plasma zinc levels should be greater than 100 mcg/dL prior to Phase 2 to minimize irritability side effects. Zinc dosages vary with body weight. A helpful rule of thumb for small patients is to provide a daily mg dosage of Zn equal to weight (lbs) plus 15-20 mg. For example, a 40 lb child would receive 55-60 mg/day during Phase 1. In addition, we recommend the following augmenting nutrients be given with the Zn: Pyridoxal-5-Phosphate, Manganese Gluconate, and Vitamins C and E. Also, Taurine may be used for patients with seizure tendencies. We have developed a compounded supplement for Phase 1, which we call the “Metabolic Primer”.

Phase 2: After Phase 1 is completed, GSH, Se, and the 14 amino-acid constituents of MT are introduced gradually, as tolerated. These nutrients are available in a compounded blend called the MTP supplement. Continuation of casein/gluten-free diets, probiotics, the Metabolic Primer, and other ongoing therapies is recommended. http://www.healing-arts.org/children/mtpromotion.htm

Detoxification for Heavy Metals as a Treatment for Autism Lewis Mehl-Madrona, M.D., Ph.D. The concept behind detoxification is that heavy metals have accumulated in the child and that removal of these heavy metals (and other toxins) will improve symptoms. Some parents have reported that the effects of detoxification are as dramatic as those found with secretin. Nevertheless, since we do not yet know how biologically active secretin is (it could be working because of the Pygmalion Effect or working in subsets of children for reasons completely unrelated to current theory), we do not know with certainty whether detoxification is working due to biological principles or do to parents’ expectations.

One source of heavy metals is thought to be the timerosol in vaccines which is associated with mercury. The first step is often testing to determine if heavy metals are present. Typically, a 24 hour urine is obtained for heavy metals and then a dose of DMSA is given and the 24 hour urine is repeated. If heavy metals are present, they should increase when a chelating agent is given. Doctor’s Data, Great Smokies Smokies Labs and Great Plains Laboratories do these tests. During chelation therapy, lead is thought to come out first, then mercury, then tin. Typical treatments include the administration of DMSA, 10 mg/kf three times per day for three days and off 11 days. DMPS can be added for additional boosting of effect. Adding lipoic acid is thought to help remove mercury from the Central Nervous System. Detoxification is a long process and may take months. Liver enzymes and a CBC should be obtained – at first monthly, and then at regular intervals of 1-3 months to be sure that no toxicity from the DMSA is developing. http://www.healing-arts.org/children/detoxification.htm  

Amy S. Holmes, M.D.

Autism: Treatment-Chelation of Mercury

We currently have over 500 autistic patients under treatment with DMSA ranging in age from 1 to 24 years old. In general, we do not expect to see any behavioral, language, or social improvements until at least some of the CNS mercury has been removed. As of 1/15/01, we had 85 patients who had finished DMSA alone and had completed at least 4 months of DMSA + lipoic acid. The results of treatment in these patients are presented below:

Once lipoic acid is added, we usually track mercury excretion via tests of fecal mercury. We have noticed a large dependence of excretion on age of patient with the younger patients excreting much more mercury than the older patients. We think this difference in rapidity of excretion may explain the differences in response between the various age groups. We have 6 patients, all 1 to 2 years of age who are finished with treatment by measurements of urinary and fecal mercury excretion. These 6 patients are “normal” by parent reports and repeat psychological testing. We have no children over the age of 2 who are finished with treatment. The rapidity of excretion seems to decrease markedly with each additional year of age. There are several children, mostly in the younger age groups, who have made remarkable progress to the point of being able to be mainstreamed in school, but who are still have some “oddities” of behavior — none of these children have completed treatment yet. These are very early results, but appear very promising. As more data is gathered, outcomes will be better able to be predicted, including length of treatment as well as ultimate prognosis. http://www.healing-arts.org/children/holmes.htm 

Amy S. Holmes, M.D.